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Textbook of human genetics
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Supplement 4. Mitotic division: Supplement 5. Some examples of simple Mendelian genetics. Supplement 6. Ecological niches and animal diversity. Supplement 7. Adaptive radiation as illustrated by the Hawaiian honey creepers. Supplement 8. What the evolution of the horse really shows: Supplement 9. The human numbers game.
Supplement Some speculations on the origin of human speech.
Supplement Il. How do those old men get all the girls?
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More information on mutations. Selection and city life. The impact of the new biology.
New York: Oxford University Press This is a comprehensive textbook of human genetics with many examples and pedigrees. It is as up-to-date as any book in this rapidly burgeoning field can ever hope to be. Suggested exercises appear after each chapter.
Introduction, mitosis, mitosis in reproduction.
Spermatogenesis, oogenesis, the normal chromosome set. Changes in number, Ploidy and Somy, autosomal trisomies, gonosomal abnormalities of number, sexual differentiation, sex chromatin analysis, mosaicism, gonosomalsyndromes of number, the XYY anomaly and behaviour, other disorders of sexual development, chromosomal rearrangement, interchromosomal exchanges, interchromosomal two-break aberrations, multiple-break aberrations, the causes of chromosomal aberrations.
The chromosomal theory, the gene theory, the molecular concept. Dominance, how genes act, pleitrophism. Variable expressivity, incomplete penetrance, age of onset, sex differences in gene expression, causes of variable expressivity, phenocopies, lethal genes.
Probability, what the genetic ratios mean, empiric probability, simplifying probability, calculations, significant deviation from expected ratios, special tests for significance, confidence intervals. X-linkage, terminology, some features of sex-related inheritance, Xlinked conditions, dosage compensation and the Lyon hypothesis, doubtful X-linkage, maternal inheritance.
The types of linkage, informative matings for linkage study, modern methods of estimating linkage, known linkage groups, chiasma frequencies, autosomal chromosomai mapping, mapping the X-chromosome.
Methods of ascertainment, correction of truncate complete selection, correction for truncate single selection. Derivation of the random mating law, random mating and multiple loci, genetic inferences from the random mating law, population associations. Terminology, relationship and consanguinity, the general theory of inbreeding, calculating the inbreeding coefficient, uses of the inbreeding coefficient, consanguinity and recessive inheritance, general effect of inbreeding.
Genes and environment, frequency of multiple births, the causes of twinning and other multiple births: The problem, physiological insights: Complementary gents, epistatic genes, indirect epistasis, the Operon theory, duplicate loci, additive genes.
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Mutation, mutation rates, total mutation rates, reverse mutation, significance of the mutational equilibrium. Experimental mutagenesis, ionizing radiations.
Natural selection, selection against a single allele, selection against one homozygote, selection favoring heterozygotes against both homozygotes, selection against heterozygotes only, genetic drift, which evolutionary forces are at work?
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